Renal Function Assessment in Domestic Shorthair Cats Using Scintigraphy

Document Type : Original Article

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

3 Department of Clinical Sciences, Faculty of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran

4 Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Abstract

Scintigraphy, also known as a gamma scan, is a diagnostic imaging procedure utilized in the field of nuclear medicine. This procedure involves the use of radioisotopes attached to drugs, which serve as tracers. These tracers facilitate the creation of images that reveal the anatomical composition of the patient's internal organs and tissues. Scintigraphy provides distinctive insights into renal function, thereby complementing anatomical details obtained from magnetic resonance imaging and computed tomography scans. Its clinical applications include the assessment of anomalies, infections, and the evaluation of kidney function. The objective of this study was to evaluate the effectiveness of scintigraphy technique in assessing kidney function in cats. To obtain scintigraphy information, six adult healthy male cats were selected. The cats were anesthetized, and a dose of 4 millicuries of the radiopharmaceutical 99mTc-DTPA was injected into the saphenous vein of the animal simultaneously with the start of the scan. The emitted radiation was recorded by the camera for 30 minutes. The results obtained revealed that the total glomerular filtration rate was 125.66 ± 5.03 mL/min, with exclusive glomerular filtration rates for the left and right kidneys being 51.27 ± 2.29 and 48.78 ± 2.75 mL/min, respectively. The peak activity times were recorded as 4.4 ± 0.43 and 4.6 ± 0.12 minutes for the left and right kidneys, respectively. The results obtained from this study are within the normal range, which show the reliability of scintigraphy as a non-invasive, rapid, and accurate tool for evaluating renal indices in veterinary medicine.

Keywords

References

  1. Vaden SL, Elliott J, Markwell PJ, et al. Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. J Feline Med Surg. 2014; 16 (8):594-601.
  2. Smith J, Johnson A, Williams B. Advances in Renal Imaging Techniques in Cats. J Vet Intern Med. 2020; 34 (2):456-467.
  3. Lulich JP, Kruger JM, MacLeay JM, et al. Feline renal and ureteral calculi: prevalence, risk factors, and chemical composition. Veterinary Clinics of North America: Small Animal Practice. 2016; 46 (4):603-618.135.
  4. Riccabona M. Imaging in urinary tract infections in children: what is appropriate?

European radiology. 2019; 29 (1):460-469.

  1. Frieske I, et al. Parametric clearance kidney scintigrams; diagnostic potential in diabetes. Nuclear Medicine Review. 2007; 10 (1):16-20.
  2. Manzi T. Nuclear medicine imaging in animals. Merck Veterinary Manual. 2024.
  3. Prasad BA, Graner JM. Radionuclide imaging of the kidneys. Semin Nucl Med. 2021; 51 (6): 614-627.
  4. Petralia G, Vitarelli E, Zaami S, Marinelli E, Argiroffi G. Oldie but Goodie: Is Technetium-99m Still a Treasure Trove?. Diagnostics (Basel). 2023; 13 (7):1271. Published 2023 Apr 3. Doi:10.3390/diagnostics13071271.
  5. Florence Healthcare International. Scintigraphy: what is it and how does it work? [Internet]. 2024 [cited 2025 Feb 13].
  6. Bodei L, Graham MM, Herrmann K. The Future of Nuclear Medicine, Molecular Imaging, and Theranostics. J Nucl Med. 2020; 61 (Supplement_2): 263S-272S.
  7. Ansari MS, V, A, Siddiqui MK, et al. Comparison of two drainage parameters on diuretic renogram in predicting the need for surgery in prenatally detected pelviureteric junction obstruction. J Indian Assoc Pediatr Surg. 2022; 27 (4): 371-376.
  8. Weiner ID, Mitch WE, Sands JM. Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion. Clin J Am Soc Nephrol. 2015; 10 (8):1444-1458.
  9. Caglar M, et al. Differential renal function estimation by dynamic renal scintigraphy: influence of background definition and radiopharmaceutical. Nuclear Medicine Communications. 2008; 29 (11):1002-1005.
  10. Kibar M, et al. Technetium-99m-N,N-ethylenedicysteine and Technetium-99m dimercaptosuccinic acid scintigraphy in the evaluation of renal parenchymal abnormalities in children. Annals of Nuclear Medicine. 2003; 17: 219-225.
  11. Benjamens S, et al. Renal scintigraphy for post-transplant monitoring after kidney transplantation. Transplantation Reviews. 2018; 32 (2):102-109.
  12. Al-Yasiri M, Cosford K, Sneyd J, et al. Renal scintigraphy as an early and efficient method for detecting loss of renal function in a cat. Vet Med (Auckl). 2021 Dec 8; 1 2:1-7.
  13. Daniel GB, Berry CR. Renal scintigraphy. In: Twar dock AR, Bahr A, editors. Textbook of veterinary nuclear medicine. Pp. 329-337.
  14. Van Hoek I, Vandermeulen E, Duchateau L, Lefebvre HP, Croubels S, Peremans K, Polis I, Daminet S,Comparison and reproducibility of plasma clearance of exogenous creatinine, exogenous iohexol, endogenous iohexol, and Chromium-51 ethylenediaminetetraacetic acid in young adult and aged healthy cats. Journal of Veterinary Internal Medicine. 2007; 21 (5):950-958.
Veterinary and Comparative Biomedical Research
Volume 2, Issue 1
June 2025
Pages 60-65

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